ADME-Tox studies are a crucial part of the drug discovery process, as they can save development costs and time, and reduce the likelihood of failure at a later stage.
Our ADME-Tox Services
We carry out a wide range of studies in the field of ADME-Tox, with a top-notch knowledge in drug metabolism, drug-drug-interactions & quantitative bioanalysis. We are a true chameleon in the way we work as everything can be designed according to the customer’s needs and requirements.
All of the services include comprehensive study consulting, enabling us to create the most ideal study plan for your needs. The state-of-art data quality is ensured by optimising the conditions according to the compounds instead of using generic protocols.
Customer’s in-house procedures can easily be adapted to deliver data produced previously in similar conditions. We can interpret the data for you and help to understand the real meaning of the numerical values and observations. By nailing data together from several studies we can reveal their combined information, in a more in depth manner than what each single study would tell.
The form and level of reporting can be optimised to meet your needs; from short and precise spreadsheet to full comprehensive report with recommendations for future studies.
ADME-Tox in Brief
ADME-Tox (Absorption, Distribution, Metabolism, Excretion and Toxicity) studies are conducted during the discovery, lead optimisation, and preclinical development phases to provide information for characterisation and ranking of the compounds based on their properties, and to predict their fate after administration into the human body. At clinical development this same information related to pharmacokinetics, metabolism and toxicity is collected to enable and confirm effective and safe use of the drugs.
The overall process of finding the best candidate for clinical development is long and complicated, requiring huge amount of studies and constant redesign of the chemical entities under development. The compound’s ADME-Tox properties must be good enough to enable drug-like behaviour in the body, and still to maintain the function and potency towards the aimed target in the body.