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Protein MW and structural characterisation (LC/MS)

Intact molecular weight analysis of protein by mass spectrometry is a fast and efficient way to confirm purity, homogeneity and molecular weight of the protein analyte. The samples are analysed using high resolution LC/MS system. In the case of antibodies, various treatments can be applied to verify the molecular weights of heavy and light chains of the antibody or other enzymatically produced sub-units, to enable more precise characterisation of the target molecule. In addition, the effect of different glycosylations or other post-translational modifications on the molecular weight can be observed.