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Inhibition towards other Metabolising Enzymes

Some compounds are not significantly metabolized by CYP or UGT enzymes and instead they can be metabolized by other enzymes, such as sulfotransferases (SULT), flavin containing mono-oxygenases (FMO), monoamine-oxidases (MAO), N-acetyltransferases (NAT), aldehyde oxidase (AOX) or carboxylesterases (CE). These enzymes can also be inhibited by drugs resulting in drug-drug interactions. Therefore, we offer inhibition studies towards these less common drug metabolizing enzymes as part of our drug-drug interaction services. These assays are available using recombinant enzymes with specific substrates and several inhibitor concentrations, delivering IC50 values towards specific enzymes.