Our services for In Vitro Metabolism research
Our core expertise and the origin of our services lie in drug metabolism studies. We offer high quality in vitro metabolism services to evaluate the metabolic fate of your compound not only in the most common drug metabolising tissue, liver, but also in extrahepatic tissues, such as intestine, kidney, lung or skin. The assays are optimised for metabolite identification and profiling or measuring in vitro clearance.
The in vitro metabolism assays are performed using any available enzyme source from multi-species hepatocytes to subcellular fractions and recombinant enzymes with high quality analytical UPLC/HR-MS-instrumentation. Studies for screening reactive drug metabolites and evaluation of acyl-glucuronide conjugate reactivity are included, as well as elucidation of the enzymes and their isoforms involved in the metabolism of your compound (CYP/UGT/SULT/FMO/MAO/CE/NAT). Also in vitro - in vivo extrapolation and PBPK modelling is available.