Our services for in vivo DMPK research
Our in vivo drug metabolism and pharmacokinetic (DMPK) services cover a complete range of different animal studies in several species. We have AAALAC-accredited in-house animal facilities housing mice and rats, and studies with other species are performed together with chosen European in-life partners. The partner for each study is chosen based on the study requirements (animal species, sample type, radiolabeled vs non-labeled compound). We manage the whole process for you; from study planning to bioanalytical tasks (LC/MS/MS, LC/HR-MS, LC/radiodetection), pharmacokinetic evaluation and reporting.
Samples for bioanalytics and pharmacokinetic evaluation from animal work performed by the customer or other in-life-site are also accepted. These studies often include identification of circulating or excreted metabolites, analysing known biomarkers, as well as evaluation of metabolites’ pharmacokinetics with respect to the parent drug or multispecies metabolite profiling.
From a drug safety perspective, we offer correlation of metabolite exposure between human and preclinical species and thus identification of metabolites disproportionate or unique in human. This can be done by comparing the in vivo metabolite profiles from animal species to in vitro human models and characterising in vivo human metabolites from FIM, SAD, MAD or human ADME studies with cold or radiolabeled compounds against the preclinical animal samples. More detailed description of this service can be found on our Safety Metabolism page.