The aim of the first e-book in our ADME-Tox e-book series is to help readers understand the importance of ADME studies in drug discovery and development, and to shed light more closely on drug metabolism studies. In the pages of this book you will learn the key ideas and concepts needed to conduct in vitro metabolism studies in a high-quality manner.

Normally for a drug candidate to reach clinical research phase, a series of compounds must be subjected to a battery of in vitro and in vivo tests to weed out the ones with poor pharmacokinetic / pharmacological qualities. This book covers the most essential in vitro metabolism studies, such as metabolic stability and metabolite profiling & identification, and even goes into detail about chemically reactive metabolite characterisation. In addition to incubation conditions for these studies, the most commonly applied analytical methods are also discussed in detail, and instructions are given on how to use the data from in vitro studies to predict in vivo pharmacokinetics.