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Tissue Binding

According to their physicochemical properties (e.g. lipophilicity and solubility) compounds can bind to different kinds of tissues, such as fat, brain, liver, and kidney, causing accumulation of the compound in the body outside of blood circulation. Accumulation in tissues affects the PK profile of the compound and can prolong the body’s exposure to the compound leading to toxicity.

The degree of tissue binding of study compounds are elucidated using rapid equilibrium dialysis (RED) or ultrafiltration in tissue homogenate, followed by analysis of the samples by LC/MS/MS.