File download
Send files
Remove all

Our services for Quantitative Bioanalysis research

We offer quantitative bioanalytical services either as a part of complete in vivo DMPK packages, or after the delivery of samples by customer or their preferred in-life-partner. Modern state-of-the-art equipment including LC/MS/MS and LC/HR-MS systems are used for the studies, and chosen depending on the nature and need for each study. A variety of sample preparation techniques (SPE, ion exchange, LLE, SLE, protein precipitation) and different levels of method prequalification/validation can be applied, depending on the biological matrix, analyte properties, and your requirements. Analysis of radiolabeled compounds with UPLC-online-radio detection is also available.

In highly sensitive and selective UPLC/MS/MS –analysis, with a triple quadrupole mass spectrometer, both the parent drug and its known metabolites can be analysed at the same time. If using UPLC/HR-MS, also unknown metabolites can be analysed from the same data together with the known target compounds, also enabling identification of the detected metabolites. With both approaches, semi-quantitative metabolite profile can be provided based on standard samples prepared for the parent compound. Also, analysis of known biomarkers is possible. 

For additional information please go to in vivo DMPK.