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Admescope Blog

A typical workflow in a preclinical pharmacokinetic experiment

25 February 2020

Despite a good part of ADME research in drug discovery and preclinical development can be performed using various in silico or in vitro systems, eventually it becomes necessary to evaluate also the pharmacokinetic (PK) profile in animals to elucidate in vivo DMPK properties of the drug candidates. This blog post summarises the components of a typical early PK study.
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Metabolites in safety testing (MIST) – How to ensure human metabolites are safe

27 January 2020

During drug development, also the safety of drug metabolites should be considered early enough to avoid massive delays in the progress of the project. There are few important things to keep in mind when investigating the safety of human metabolites, and Admescope’s Head of Safely Metabolism Dr Johanna Haglund will highlight these.
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Admescope's 2019 in a nutshell - an excellent year!

9 January 2020

I could say that the last two weeks of December are in many ways the best weeks of the year. The busiest time of the year is just over, it is couple of days slowing down towards the well-earned holidays and the atmosphere is just great. Yet then after the Christmas it is the best days to have a holiday, as phone is not ringing and no urgent emails are dropping to the inbox.
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Preclinical formulations for pharmacokinetic studies

25 November 2019

When new drug compounds are synthetized, typically as solid powders, at the preclinical stage many properties of the compounds are not known. Apart from biological activity, for example particle size and crystal structure play important roles in further research for the compound. In many in vitro studies, the compound is just fully solubilized in solvent eliminating the issues described above.
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Responsible treatment of laboratory animals

17 October 2019

Admescope has always been committed to advance the ethical use of animals in science and to demonstrate its significance, in March 2019 we applied for an accreditation by AAALAC International. The accreditation stands for high quality animal care and use in research organisations, where the primary standards and legislation are followed.
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Tags: , in vivo DMPK