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Admescope Blog

In vitro toxicology screening in drug development

20 March 2018

Prior to IND approval drug candidates must go through a comprehensive battery of in vitro and in vivo toxicology testing to maximise safety in clinical trials. For ethical reasons and the costly nature of the in vivo animal tests the pharmaceutical industry relies more and more on in vitro methods for toxicity testing especially in drug discovery phase. To elucidate this topic further, we interviewed an expert on the subject, Dr Sanna-Mari Aatsinki.
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Tags: , ADME, Toxicology

2017 – Hard work and good times

17 January 2018

The twelve months of the year 2017 rushed through like Usain Bolt, faster than ever and celebrating with hands in the air on the way. Or in other words, it was a very nice year for Admescope, being the strongest period in our history, with 20% increase in revenue and tens of new satisfied customers.
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Tags: , Admescope

The new FDA draft guidance on DDI studies – how does it affect in vitro studies?

1 December 2017

Recently FDA released new draft guidance on drug-drug interaction (DDI) studies. Compared to the previous one issued in 2012, also the structure is revised as there is now two complementary documents. The “In Vitro Metabolism- and Transporter –Mediated Drug-Drug Interaction Studies” focuses on in vitro approaches to evaluate potential interaction risk,
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Tags: , ADME, DDI, Transporters

ADME-Tox e-books – why are we doing these?

16 August 2017

Working at a CRO is not only about providing research services, but also about helping and supporting customers in different ways throughout the process. We have the pleasure to work with a wide variety of customers, ranging from small biotech and academic research groups to Big Pharma companies.
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HR-MS – when does it make a difference?

6 June 2017

In addition to knowledge and knowhow regarding the early phase ADME studies, also the analytical instrumentation applied plays a big role in their success. The importance of using liquid chromatography coupled to high resolution mass spectrometry (LC/HR-MS) in drug discovery and preclinical phase ADME studies has been emphasized for few years, but when does it really make a difference? To elucidate the topic further, we interviewed an expert in the field, Dr Ari Tolonen.
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