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Admescope Blog

Preclinical formulations for pharmacokinetic studies

25 November 2019

When new drug compounds are synthetized, typically as solid powders, at the preclinical stage many properties of the compounds are not known. Apart from biological activity, for example particle size and crystal structure play important roles in further research for the compound. In many in vitro studies, the compound is just fully solubilized in solvent eliminating the issues described above.
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Responsible treatment of laboratory animals

17 October 2019

Admescope has always been committed to advance the ethical use of animals in science and to demonstrate its significance, in March 2019 we applied for an accreditation by AAALAC International. The accreditation stands for high quality animal care and use in research organisations, where the primary standards and legislation are followed.
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Tags: , in vivo DMPK

It's getting close to Midsummer

18 June 2019

The first half of 2019 is nearing its end and I can tell you that the time has truly flown by. The Sales and marketing team has been keeping busy flying and driving around Europe these past few months. We’ve visited seven different countries on roadshows, attended several conferences and as a result met a lot of new interesting people and old acquaintances.
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Tags: , Admescope

ADME – how to get started?

29 May 2019

During preclinical drug development, the number of compounds decreases from hundreds or thousands to the one entering the clinical trials. Understanding the ADME properties is essential to guide the decision makers and hence, ADME studies constitute an important part of preclinical drug development. When initiating this line of work for the first time, it may appear a bit puzzling. So, let’s have a simplified overview how get started with small molecules.
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Tags: , ADME, pre-clinical

Protein quantification with mass spectrometry

3 May 2019

The development of analytical techniques has enabled applying mass spectrometry methods also for protein quantification from biological samples. The use of LC/MS brings in more analytical potential due to its versatility and accuracy and hence, its importance as an analytical tool for protein characterisation is increasing. If not being familiar with the topic, it may be interesting to have a peek how proteins are quantified from biological matrixes with LC/MS.
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Tags: , Biologics