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Admescope Blog

In vitro toxicology screening in drug development

20 March 2018

Prior to IND approval drug candidates must go through a comprehensive battery of in vitro and in vivo toxicology testing to maximise safety in clinical trials. For ethical reasons and the costly nature of the in vivo animal tests the pharmaceutical industry relies more and more on in vitro methods for toxicity testing especially in drug discovery phase. To elucidate this topic further, we interviewed an expert on the subject, Dr Sanna-Mari Aatsinki.
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Tags: , ADME, Toxicology

The new FDA draft guidance on DDI studies – how does it affect in vitro studies?

1 December 2017

Recently FDA released new draft guidance on drug-drug interaction (DDI) studies. Compared to the previous one issued in 2012, also the structure is revised as there is now two complementary documents. The “In Vitro Metabolism- and Transporter –Mediated Drug-Drug Interaction Studies” focuses on in vitro approaches to evaluate potential interaction risk,
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Tags: , ADME, DDI, Transporters

ADME-Tox e-books – why are we doing these?

16 August 2017

Working at a CRO is not only about providing research services, but also about helping and supporting customers in different ways throughout the process. We have the pleasure to work with a wide variety of customers, ranging from small biotech and academic research groups to Big Pharma companies.
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PBPK – what it is for?

13 December 2016

In addition to lab work also various modeling tools have developed rapidly in the last decade to support drug discovery and development. One interesting modeling tool is PBPK, physiologically based pharmacokinetic modeling. To elucidate the topic further we interviewed an expert in the field, Dr Aki Heikkinen.
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Tags: , ADME, PBPK

Behind the scenes of our next video

5 August 2016

We recently had an exciting day filming our next marketing video, with an authentic setting in our own labs with our own staff members. So, we wanted to give you an authentic view on our daily work and to literally take you for a peek behind the scenes of the shooting session.
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