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Admescope Blog

ADME – how to get started?

29 May 2019

During preclinical drug development, the number of compounds decreases from hundreds or thousands to the one entering the clinical trials. Understanding the ADME properties is essential to guide the decision makers and hence, ADME studies constitute an important part of preclinical drug development. When initiating this line of work for the first time, it may appear a bit puzzling. So, let’s have a simplified overview how get started with small molecules.
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Tags: , ADME, pre-clinical

In vitro toxicology screening in drug development

20 March 2018

Prior to IND approval drug candidates must go through a comprehensive battery of in vitro and in vivo toxicology testing to maximise safety in clinical trials. For ethical reasons and the costly nature of the in vivo animal tests the pharmaceutical industry relies more and more on in vitro methods for toxicity testing especially in drug discovery phase. To elucidate this topic further, we interviewed an expert on the subject, Dr Sanna-Mari Aatsinki.
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Tags: , ADME, Toxicology

The new FDA draft guidance on DDI studies – how does it affect in vitro studies?

1 December 2017

Recently FDA released new draft guidance on drug-drug interaction (DDI) studies. Compared to the previous one issued in 2012, also the structure is revised as there is now two complementary documents. The “In Vitro Metabolism- and Transporter –Mediated Drug-Drug Interaction Studies” focuses on in vitro approaches to evaluate potential interaction risk,
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Tags: , ADME, DDI, Transporters

ADME-Tox e-books – why are we doing these?

16 August 2017

Working at a CRO is not only about providing research services, but also about helping and supporting customers in different ways throughout the process. We have the pleasure to work with a wide variety of customers, ranging from small biotech and academic research groups to Big Pharma companies.
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PBPK – what it is for?

13 December 2016

In addition to lab work also various modeling tools have developed rapidly in the last decade to support drug discovery and development. One interesting modeling tool is PBPK, physiologically based pharmacokinetic modeling. To elucidate the topic further we interviewed an expert in the field, Dr Aki Heikkinen.
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Tags: , ADME, PBPK