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Admescope Blog

A typical workflow in a preclinical pharmacokinetic experiment

25 February 2020

Despite a good part of ADME research in drug discovery and preclinical development can be performed using various in silico or in vitro systems, eventually it becomes necessary to evaluate also the pharmacokinetic (PK) profile in animals to elucidate in vivo DMPK properties of the drug candidates. This blog post summarises the components of a typical early PK study.
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Preclinical formulations for pharmacokinetic studies

25 November 2019

When new drug compounds are synthetized, typically as solid powders, at the preclinical stage many properties of the compounds are not known. Apart from biological activity, for example particle size and crystal structure play important roles in further research for the compound. In many in vitro studies, the compound is just fully solubilized in solvent eliminating the issues described above.
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Responsible treatment of laboratory animals

17 October 2019

Admescope has always been committed to advance the ethical use of animals in science and to demonstrate its significance, in March 2019 we applied for an accreditation by AAALAC International. The accreditation stands for high quality animal care and use in research organisations, where the primary standards and legislation are followed.
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Tags: , in vivo DMPK

Metabolites in safety testing (MIST)

5 February 2019

After administration into a body, the drug is usually metabolised into metabolites, which may also be associated with toxic effects. This is why the MIST strategy has evolved to ensure that human metabolites have been adequately covered in the preclinical safety studies. Admescope site manager Sweden Dr Johanna Haglund will describe how to tackle this question.
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Tags: , in vivo DMPK

Microsampling in in vivo PK studies

5 July 2018

Microsampling technology in drug discovery and development has been gaining a serious foothold within the industry over the last decade. We at Admescope have been providing microsampling as a part of our in vivo PK services for well over a year now and this feels like a good time to let Dr Janne Mannila, our Head of In vivo PK studies share his experiences with microsampling over an interview.
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Tags: , in vivo DMPK