MIST evaluation toolbox – what is in there? Part 4
25 February 2022
The overall aim of the safety metabolism studies is to better understand human metabolism. How is the drug cleared, what metabolites are formed, what is the relative exposure to these and can they be considered safety tested through adequate exposures in toxicology species. The 4th part of this blog series concerns the MIST analysis, i.e. the metabolite exposure comparison performed utilising samples from repeated dose studies in man and toxicology species.Read more
MIST evaluation toolbox – what is in there? Part 3
7 October 2021
In the first part of this blog series, Dr Johanna Haglund introduced what are the first steps in the Metabolites in Safety Testing evaluation (MIST). The second part advised how to proceed after in vitro cross-species comparison between human and safety species. This third part is about in vivo human MetID.Read more
MIST evaluation toolbox – what is in there? Part 2
15 June 2021
In Part 1, Dr Johanna Haglund (Head of Safety Metabolism) described the first steps to be taken in the Metabolites in Safety Testing evaluation (MIST) and in this second part, she will elaborate how to proceed after in vitro cross species comparison between human and safety species.Read more
