MIST evaluation toolbox – what is in there? Part 2
15 June 2021
In Part 1, Dr Johanna Haglund (Head of Safety Metabolism) described the first steps to be taken in the Metabolites in Safety Testing evaluation (MIST) and in this second part, she will elaborate how to proceed after in vitro cross species comparison between human and safety species.Read more
MIST evaluation toolbox – what is in there? Part 1
5 March 2021
Safety testing of drug metabolites is often discussed as ”MIST (metabolites in safety testing) evaluation”, according the guidelines set up by the FDA and ICH. The MIST evaluation is a multi-step approach to ensure human metabolites are safety tested. This can be seen as a MIST toolbox, where each tool is used in a pragmatic approach at the time they become possible and available. It is all about understanding the risk for potential metabolite safety issues early in the development of a candidate drug. In this blog post, Dr Johanna Haglund (Head of Safety Metabolism) sheds light on the metabolites in safety testing theme and how to start the MIST evaluation.Read more