A typical workflow in a preclinical pharmacokinetic experiment
25 February 2020
Despite a good part of ADME research in drug discovery and preclinical development can be performed using various in silico or in vitro systems, eventually it becomes necessary to evaluate also the pharmacokinetic (PK) profile in animals to elucidate in vivo DMPK properties of the drug candidates. This blog post summarises the components of a typical early PK study.Read more
Preclinical formulations for pharmacokinetic studies
25 November 2019
When new drug compounds are synthetized, typically as solid powders, at the preclinical stage many properties of the compounds are not known. Apart from biological activity, for example particle size and crystal structure play important roles in further research for the compound. In many in vitro studies, the compound is just fully solubilized in solvent eliminating the issues described above.Read more
ADME – how to get started?
29 May 2019
During preclinical drug development, the number of compounds decreases from hundreds or thousands to the one entering the clinical trials. Understanding the ADME properties is essential to guide the decision makers and hence, ADME studies constitute an important part of preclinical drug development. When initiating this line of work for the first time, it may appear a bit puzzling. So, let’s have a simplified overview how get started with small molecules.Read more
