New article on physiologically based pharmacokinetic modeling
21 October 2021
Admescope’s top expert on physiologically based pharmacokinetic (PBPK) modeling, Dr Aki Heikkinen, has yet again contributed his scientific expertise, along with several other world leading experts in PBPK, to a collaboration which resulted in an interesting article published earlier this year. The article assesses PBPK modeling as a tool for predicting intestinal metabolism of UGT substrates. Full article is available here.
Expanding our in vitro metabolism services
We have included aldo-keto reductase (AKR) and carbonyl reductase (CR) to our non-CYP metabolism service portfolio. Both of these NADPH-dependent enzymes catalyze ketone groups to alcohols and can be relevant for the metabolism of ketone containing compounds. Check our complete list for non-CYP mediated metabolism services on our website.