New analytical instrumentation - greater capacity for metabolism services!
22 June 2016
As a response to increased demand for drug metabolism services, we installed a second Q Exactive™ mass spectrometer with Waters Acquity UPLC. This is a great addition to other high-resolution mass spectrometers we have from ThermoFisher Scientific and Waters.
Q-Exactive™ Orbitrap is a perfect tool for metabolite profiling and identification workflows, and due to its excellent dynamic range and spectacular sensitivity and specificity also well suitable for quantitative bioanalysis.
We offer high-quality services to evaluate the metabolism of your compounds:
o in vitro clearance and reaction kinetics with in vitro – in vivo extrapolation
o analysis of metabolic hot-spots
o comprehensive multi-species metabolite profiling & identification
o identification of metabolizing enzymes from variety of enzyme families
o non-CYP mediated and extrahepatic metabolism
o screening of reactive metabolites using various trapping agents
o stability and reactivity of acyl glucuronide conjugates
o metabolite purification and structural elucidation using NMR
o in vivo metabolism services
Please visit our website to learn more about our drug metabolism services.
High resolution Orbitrap and Q-TOF-MS mass spectrometers bring unbeatable value for metabolism studies. In addition, there is a growing trend of using high-resolution mass spectrometers in quantitative PK-bioanalysis; as one run only is enough to generate all the data. Later on we can go back and re-process the existing data to elucidate metabolite structures and metabolite profiles, no need for new labwork or analyses!
We are growing again!
We are happy to introduce the newest member of our team, Dr Anne-Mari Moilanen, who recently joined us as Research Scientist. Anne-Mari brings in many years of expertise in cell based assays. Welcome Anne-Mari!